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Low-fibre diet linked to leaky gut: Mouse study

Low-fibre diet linked to leaky gut: Mouse study

Mice fed with a low-fibre, Western Style Diet (WSD) for 8 weeks developed increased gut permeability compared with their littermates fed a standard (control) chow diet, found researchers from the University of Gothenburg.

The WSD fed mice also displayed a lower rate of gut mucous growth than the control group. Increased permeability of the mucous layer and the reduced growth rate began to occur in as little as three days after starting the WSD feeding.

The scientists also found that the above changes were accompanied by an alteration in the gut bacteria make-up. 

“Low-fibre diets alter bacterial composition and influence what they produce,” ​commented study director Professor Gunnar Hansson. “The result can be greater penetrability that affects the body’s cells.

“We clearly illustrated the rapid process by which the mucus layer responds to dietary modifications and subsequent bacterial changes,”​ he added.

Increased Proteobacteria

Among the most notable changes in microbiota composition was an increase in numbers of Proteobacteria – a type of bacteria that has previously been linked with inflammation.

“Analysis of colonic mucosa-associated bacterial composition revealed a lower abundance of Bacteroidetes upon WSD feeding and a higher abundance of Proteobacteria,”​ revealed co-senior author Professor Fredrik Bäckhed.

The high abundance of Proteobacteria was due to a bloom of the pathogenic genus Helicobacter.

Additionally, WSD fed mice suffered a rapid decrease in the proportion of fibre-degrading bacteria Bifidobacterium. ​The amount of short-chain fatty acids (SCFAs), a fermentation product of fibre, was also found to be lower in the mice on the WSD. This finding strongly suggests that the lowered Bifidobacterium ​abundance was due to the lack of fibre in the diet, the researchers noted.